Leonard V. Favreau: search on Z-Library

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1

Validation of higher-throughput high-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry assays to conduct cytochrome P450s CYP2D6 and CYP3A4 enzyme inhibition studies in human liver microsomes

Inhou Chu, Leonard Favreau, Tony Soares, Chin-chung Lin, Amin A. Nomeir

Journal:

Rapid Communications in Mass Spectrometry

Year:

2000

Language:

english

File:

PDF, 166 KB

english, 2000

2

Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active γ-secretase inhibitors

Mark D. McBriar, John W. Clader, Inhou Chu, Robert A. Del Vecchio, Leonard Favreau, William J. Greenlee, Lynn A. Hyde, Amin A. Nomeir, Eric M. Parker, Dmitri A. Pissarnitski, Lixin Song, Lili Zhang, Z

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 252 KB

english, 2008

3

Novel orally active morpholine N-arylsulfonamides γ-secretase inhibitors with low CYP 3A4 liability

Hubert Josien, Thomas Bara, Murali Rajagopalan, John W. Clader, William J. Greenlee, Leonard Favreau, Lynn A. Hyde, Amin A. Nomeir, Eric M. Parker, Lixin Song, Lili Zhang, Qi Zhang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 1.22 MB

english, 2009

4

Small conformationally restricted piperidine N-arylsulfonamides as orally active γ-secretase inhibitors

Hubert Josien, Thomas Bara, Murali Rajagopalan, Theodros Asberom, John W. Clader, Leonard Favreau, William J. Greenlee, Lynn A. Hyde, Amin A. Nomeir, Eric M. Parker, Dmitri A. Pissarnitski, Lixin Song

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 209 KB

english, 2007

5

Piperazine sulfonamide BACE1 inhibitors: Design, synthesis, and in vivo characterization

Jared Cumming, Suresh Babu, Ying Huang, Carolyn Carrol, Xia Chen, Leonard Favreau, William Greenlee, Tao Guo, Matthew Kennedy, Reshma Kuvelkar, Thuy Le, Guoqing Li, Nansie McHugh, Peter Orth, Lynne Oz

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 2.34 MB

english, 2010

6

The synthesis and structure–activity relationship of 4-benzimidazolyl-piperidinylcarbonyl-piperidine analogs as histamine H3 antagonists

Pauline C. Ting, Joe F. Lee, Margaret M. Albanese, Jie Wu, Robert Aslanian, Leonard Favreau, Cymbelene Nardo, Walter A. Korfmacher, Robert E. West, Shirley M. Williams, John C. Anthes, Maria A. Rivell

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 2.46 MB

english, 2010

7

Supercritical fluid chromatography/tandem mass spectrometric method for analysis of pharmaceutical compounds in metabolic stability samples

Yunsheng Hsieh, Leonard Favreau, John Schwerdt, K.-C. Cheng

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2006

Language:

english

File:

PDF, 247 KB

english, 2006

8

Chiral supercritical fluid chromatography/tandem mass spectrometry for the simultaneous determination of pindolol and propranolol in metabolic stability samples

Yunsheng Hsieh, Leonard Favreau, K.-C. Cheng, Jiwen Chen

Journal:

Rapid Communications in Mass Spectrometry

Year:

2005

Language:

english

File:

PDF, 111 KB

english, 2005

9

Fingerprinting rat liver microsomal cytochromes P-450 as a means of delineating sexually distinctive forms

John B. Schenkman, Leonard V. Favreau, John Mole, Donald L. Kreutzer, Ingela Jansson

Journal:

Archives of Toxicology

Year:

1987

Language:

english

File:

PDF, 2.40 MB

english, 1987

10

Regulation of glutathione S-transferase and quinone reductase gene expression

Thomas H. Rushmore, Leonard V. Favreau, Cecil B. Pickett

Journal:

Free Radical Biology and Medicine

Year:

1990

Language:

english

File:

PDF, 124 KB

english, 1990

11

Validation of a rapid microtiter plate assay to conduct cytochrome P450 2D6 enzyme inhibition studies

Jairam R Palamanda, Leonard Favreau, Chin-chung Lin, Amin A Nomeir

Journal:

Drug Discovery Today

Year:

1998

Language:

english

File:

PDF, 153 KB

english, 1998

12

Biochemical and immunological identity of the hepatic peroxisomal and microsomal trans-2-enoyl CoA hydratase bifunctional protein

Lynda Cook, Daniele Ghesquier, Mahmoud N. Nagi, Leonard V. Favreau, Dominick L. Cinti

Journal:

Archives of Biochemistry and Biophysics

Year:

1987

Language:

english

File:

PDF, 3.21 MB

english, 1987

13

Regioselective hydroxylation of prostaglandins by constitutive forms of cytochrome P-450 from rat liver: Formation of a novel metabolite by a female-specific P-450

David Kupfer, Ingela Jansson, Leonard V. Favreau, Anthony D. Theoharides, John B. Schenkman

Journal:

Archives of Biochemistry and Biophysics

Year:

1988

Language:

english

File:

PDF, 968 KB

english, 1988

14

Further characterization of RLM2 and comparison with a related form of cytochrome P-450, RLM2b

Kenneth E. Thummel, Leonard V. Favreau, John E. Mole, John B. Schenkman

Journal:

Archives of Biochemistry and Biophysics

Year:

1988

Language:

english

File:

PDF, 2.11 MB

english, 1988

15

Differences in the spectral interactions between NADPH-cytochrome P-450 reductase and a series of cytochrome P-450 enzymes

Paul P. Tamburini, Ingela Jansson, Leonard V. Favreau, Wayne L. Backes, John B. Schenkman

Journal:

Biochemical and Biophysical Research Communications

Year:

1986

Language:

english

File:

PDF, 315 KB

english, 1986

16

Decrease in the levels of a constitutive cytochrome P-450 (RLM5) in hepatic microsomes of diabetic rats

Leonard V. Favreau, John B. Schenkman

Journal:

Biochemical and Biophysical Research Communications

Year:

1987

Language:

english

File:

PDF, 759 KB

english, 1987

17

Cytochrome P-450 alterations in the BB/Wor spontaneously diabetic rat

Leonard V. Favreau, John B. Schenkman

Journal:

Biochemical Pharmacology

Year:

1988

Language:

english

File:

PDF, 945 KB

english, 1988

18

Dopamine D 1 /D 5 Receptor Antagonists with Improved Pharmacokinetics: Design, Synthesis, and Biological Evaluation of Phenol Bioisosteric Analogues of Benzazepine D 1 /D 5 Antagonists

Wu, Wen-Lian, Burnett, Duane A., Spring, Richard, Greenlee, William J., Smith, Michelle, Favreau, Leonard, Fawzi, Ahmad, Zhang, Hongtao, Lachowicz, Jean E.

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 262 KB

english, 2005

19

Stereochemical dynamics of aliphatic hydroxylation by cytochrome P-450

White, Ronald E., Miller, John P., Favreau, Leonard V., Bhattacharyya, Apares.

Journal:

Journal of the American Chemical Society

Year:

1986

Language:

english

File:

PDF, 1.07 MB

english, 1986

20

Discovery of potent iminoheterocycle BACE1 inhibitors

Caldwell, John P., Mazzola, Robert D., Durkin, James, Chen, Joseph, Chen, Xia, Favreau, Leonard, Kennedy, Matthew, Kuvelkar, Reshma, Lee, Julie, McHugh, Nansie, McKittrick, Brian, Orth, Peter, Stamfor

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.01 MB

english, 2014

21

Physiological and Pathophysiological Alterations in Rat Hepatic Cytochrome P450

Schenkman, John b., Thummel, Kenneth e., Favreau, Leonard v.

Journal:

Drug Metabolism Reviews

Year:

1989

Language:

english

File:

PDF, 2.23 MB

english, 1989

22

Overcoming Time Dependent Inhibition (TDI) of Cytochrome P450 3A4 (CYP3A4) Resulting from Bioactivation of a Fluoropyrimidine Moiety

Mandal, Mihir Baran, Mitra, Kaushik, Grotz, Diane, Lin, Xinjie, Palamanda, Jairam, Kumari, Pramila, Buevich, Alexei V., Caldwell, John P., Chen, Xia, Cox, Kathleen, Favreau, Leonard, Hyde, Lynn A., Ke

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 535 KB

english, 2018

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